5/20/2023 0 Comments Sequencher mtdnaTo avoid misinterpretation of data which can arise from sequencing errors as well as low-level contamination of samples, we introduced extensive QC checks. We efficiently parallelized workflow steps such as sequence alignment, per-base alignment scoring (BAQ) ( 13), and heteroplasmy and contamination detection. For handling large studies (>100 samples), we implemented new parallel mechanisms to overcome limitations of local single node architectures. Here we present mtDNA-Server, a highly scalable Hadoop-based server ( 12) for mtDNA NGS data processing. To eliminate these shortcomings, web servers were implemented (9–11), but they were limited to small input files, revealed shortcomings in usability, overloaded with parameter options, or generate poor and often unreliable results (see Supplementary Tables S1–3). These pipelines facilitate the analysis of mtDNA data, but can be challenging to install. Since the first description of analyzing mtDNA heteroplasmy on NGS devices in 2010 ( 5), several Unix command line pipelines have been presented (6–8). in mitochondrial encephalomyopathy, lactic acidosis and stroke-like episodes (MELAS) ( 4)) its origin and mechanisms to prevail as somatic mutations is largely unknown ( 1). While the role of such variants is acknowledged for some diseases (e.g. While higher error rates within NGS can be opposed with higher sequencing coverage for variant detection, interpretation of results still needs consideration when analyzing variant allele frequencies (VAF) below 10%, the detection limit for Sanger-based sequencing. Furthermore, the paradigm shift from analyzing few reliable long reads (400–800 bp) in Sanger based sequencing to millions of short reads (50–250 bp) in Next Generation Sequencing (NGS) requires new computational models and additional attention interpreting results. Artefacts became even more evident with new and more sensitive sequencing technologies ( 2, 3). The differentiation between real mutational clones and sequencing artefacts can be complex, but is crucial in researching somatic mutations in cancer, neurodegenerative diseases and aging ( 1). Heteroplasmy describes a de novo mtDNA mutation often present in only a few copies. Mitochondrial DNA (mtDNA) is maternally inherited in humans and present in thousands of copies per cell. mtDNA-Server is currently able to analyze the 1000G Phase 3 data ( n = 2,504) in less than 5 h and is freely accessible at. Our evaluation data shows that mtDNA-Server detects heteroplasmies and artificial recombinations down to the 1% level with perfect specificity and outperforms existing approaches regarding sensitivity. We validated the underlying heteroplasmy and contamination detection model by generating four artificial sample mix-ups on two different NGS devices. All computational steps are parallelized with Hadoop MapReduce and executed graphically with Cloudgene. The mtDNA-Server workflow includes parallel read alignment, heteroplasmy detection, artefact or contamination identification, variant annotation as well as several quality control metrics, often neglected in current mtDNA NGS studies. Here we present mtDNA-Server, a scalable web server for the analysis of mtDNA studies of any size with a special focus on usability as well as reliable identification and quantification of heteroplasmic variants. While several pipelines for analyzing heteroplasmies exist, issues in usability, accuracy of results and interpreting final data limit their usage. intra-individual sequence variation) to a higher level of detail. Next generation sequencing (NGS) allows investigating mitochondrial DNA (mtDNA) characteristics such as heteroplasmy (i.e.
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5/20/2023 0 Comments Sync ios heic converterHere, let's take Luma: heic to jpg converter and viewer offline as an example to illustrate how to open HEIC files on Android with Play Store Apps: Some Android apps have been made available to help its users view HEIC images since iOS 11 was released. Part 3: How to Open HEIC on Android via Play Store Apps (Come across any Dropbox issues on Android?) Tap the Photos folder to view the uploaded HEIC files, and it'll be good to go.Sign in to the Dropbox app on your Android device.Upload your HEIC pictures to the Photos folder.Log in to the app with your account and password on a computer.Download and install the Dropbox app on your Android device. How to open HEIC images in Android with Dropbox? On that of that, it supports syncing and previewing the HEIC images from an Android phone. This cloud has been widely used for file sharing and collaboration among various teams. If you do not wish to use Gmail for some reason, Dropbox, a creative cloud space serving as a HEIC viewer on Android, can help achieve just that. Part 2: How to Open HEIC File in Android with Dropbox How to Convert HEIC to PNG on Windows, Mac, and iPhone?.Access your inbox on Android, and you should be able to download and check the files on this device.Compose a new email to yourself with all of the selected HEIC files attached to it.( Can't view pictures in Android Gallery?) Select the images you want to view on your Android phone.How to open HEIC files on Android via Gmail? Can HEIC be opened on Android via Gmail? Yes! After sending an email containing HEIC photos, you can open them directly from the inbox on the target Android device. Gmail is a useful tool for our daily communication, through which we can easily sync Android contacts, messages, etc. Part 1: How to Open HEIC Files on Android over Gmail Part 4: How to Open HEIC File in Android after Converting It on PC.
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In 2003, Sony acquired the Sonic Foundry desktop product line and set up their Creative Software division and over the next 13 years, the three programs. Bring it into view with a single click to access plug-ins, plug-in presets, and search functionality. Sound Forge Pro Mac features a dedicated panel for offline plug-in processing. Record audio quickly on a rock-solid platform, address sophisticated audio processing tasks with surgical precision, and render top-notch master files with ease. Sound Forge&trade, Pro is the application of choice for a generation of creative and prolific artists, producers, and editors. 5/19/2023 0 Comments Batch image resizer lite macAlthough it is commonly used for image resizing, users can also add various effects to their images using this tool and files can also be converted to other formats with ease. This simple and basic editing tool has few valuable features to offer. It can also be used for fine-tuning of image colors, but the only drawback is that the interface is not much user-friendly. Choose batch actions and hit the start batch option to initiate selected editing task. In order to resize your batch files, simply go to the file, choose “Batch Conversion/Rename”, drag images from top part of the window to the input area. It allows users to edit, rename, resize, convert and adjust several images together. IrfanView is an excellent image editor with lots of impressive features. Supported Formats: BMP, JPG, GIF, TIFF, MP3, MOV, AVI, and many more. Top 15 Batch Image Resizers for Window/Mac/Linux: Below we have highlighted 15 most popular freeware tools that can help you to reduce the size of images on Windows, Mac OS, and Linux platform. There are so many apps that can offer you the ability to resize multiple images at a time as well so they can help you to save much of your time. 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You can always download the demo version of the game and buy the license later. You need to purchase a license to download and install Factorio. DirectX 10.1 capable GPU with 512 MB VRAM - GeForce GTX 260, Radeon HD 4850 or Intel HD Graphics 5500 The Minimum system requirements for running the game In the following article, we will see how to deploy Factorio on a Windows 2019 Server Edition dedicated server. Factorio also supports multiplayer, allowing many players to cooperate and assist each other or work against each other. You will be mining resources, researching technologies, building infrastructure, automating production, and fighting enemies. This game allows you to build and maintain factories. Publisher: Psychz Networks, March 29,2021įactorio is a construction and management simulation game developed by the Czech studio Wube Software. I have played this game on a plane on an old 2016 13-inch MacBook Pro with integrated graphics, and the game always ran great.īut as reported by some players, the update does bring a significant performance improvement for M1 and M2 Macs: Benchmarks:Īs you can see from these benchmarks, the improvements are noticeable (20%+ UPS).How to setup a dedicated server for Factorio 60+ FPS: Very Smooth: For hardcore and professional players, a luxury for most.Īs can be expected from a top-down strategy game with simple graphics, Factorio is a very forgiving game with low system requirements.45-60 FPS: Smooth: Fluid gameplay, with no perceivable stutters.30-45 FPS: Playable: Acceptable for most (most gaming consoles do this).20-30 FPS: Borderline: Can be OK in slow-paced games.Below 20 FPS: Unplayable: Laggy gameplay, full of stutters and slowdowns.These are the Rust M1 benchmarks we have gathered so far (you can find more details about the game’s Apple Silicon version here):Īs a reminder, this is how we describe the different levels of performance: Therefore, we won’t waste your time talking about Parallels, Crossover (both excellent tools, but only useful for Windows-exclusive games…), or Streaming services (this has to be said, as some guides spend entire pages talking about streaming WoW on Mac). These are the game’s official Mac requirements: RequirementsĪs mentioned before, Factorio now runs natively on Mac, and that includes Intel-based and M1 Macs. In fact, some consider it one of the greatest strategy games available today. It’s no surprise the game is considered an indie sensation in the same vein as Kerbal Space Program or Prison Architect. Featuring a top-down view and simplistic graphics, Factorio is all about the perfectly tuned mechanics and systems you can put in place to build impressive factories.įactorio has over 106,000 Overwhelmingly Positive user reviews on Steam and having played it myself, I can tell you it’s really good. You’ll have to mine resources, research technologies, build infrastructure, and automate production. In Factorio, you land on an alien planet and have to build and maintain factories to survive and fight off alien enemies. Artįactorio on Mac: Everything you need to know It is worth mentioning that it has been possible to run Minecraft natively on M1 Macs for a while nowīottom line: Factorio used to run just fine on macOS, including MacBook Airs and Mac Minis, but to receive a native Apple Silicon version is always great, as it future-proofs the game and provides M1 and M2 Macs a boost in performance. Optimizations: Added native support for M1 Macs. In fact, Factorio is one of the few AAA games that support M1 Macs with a native ARM Apple Silicon version.įactorio just received native Apple Silicon recently as part of version 1.1.7.1, released on November 4, 2022: You can absolutely play Factorio on your Mac, and that includes Intel and M1 Models. Factorio on Mac: Everything you need to know. 5/19/2023 0 Comments Microsoft excel for mac add insAdditional information will be provided by your professor. Used in Strategic Modeling and Business Dynamics People Express Simulator (DECISION 613).While we’re showing Word 2016 for Windows in the screenshot here, this option is available in the same place in other Office applications and Word for. TreePlan (DECISION 517F/K and DECISION 611) Microsoft announced new features coming to Excel for this March 2023 update. In a Microsoft Office application, you can click the Insert tab on the ribbon, click the Add-ins icon on the bar, and select Store.SensIt (DECISION 517F/K and DECISION 611).Used in Probability and Statistics and Business Computer Applications Click on Browse and direct Excel to the file you just downloaded and unblocked:įSBstats (DECISION 610, DECISION 616, DECISION 516F, AND DECISION 516K).At the bottom of the screen, click on Go. Open Excel and click on File> Options > Add-ins. ( Please make sure to save the file somewhere on your computer so that it does not get deleted or moved.)
5/19/2023 0 Comments Trauma center levels kyIn lesser order of importance, age, SBP, head AIS, mechanism, gender, and abdominal AIS were relevant to adjust for case mix. Specifically, when ISS was taken into consideration, 92% of trauma centers changed their rank by >/=3 and almost half their quartile rank by at least 1. ISS accounted for the most variation in mortality rates across trauma centers, shown by the large rank change with addition of ISS to the model. The variable that affected rankings the greatest was kept and the process was repeated in an iterative fashion until the incremental change in ranks was minimal. We then added variables singly to a risk-adjustment model to obtain adjusted probability of death. Trauma centers were ranked by crude mortality. One hundred ninety trauma centers contributing data to the National Trauma Databank (NTDB) during 2004 to 2005 were used for hospital rankings (n = 169,929 patients). We set out to identify the patient and injury-related factors that most affect case-mix across centers and thus are most likely to alter assessments of hospital performance. In part, this is due to the perceived need for extensive data required to adequately risk adjust. Few studies have focused on identifying top performers. Evaluation of trauma center performance has been limited to comparisons of observed versus expected mortality using trauma and injury severity score methodology. 5/19/2023 0 Comments Anime concept art viewIt’s rare to nail the target the first time when it comes to concept art. The critical thing to remember is that they’re all a part of the process, even the ones that are not so pleasant. It may have been a scratch that helped the art director realize a concept or an utterly wrong design. Remember how you used to be chastised in math class for not showing your work? So, what is this? Those are the workings of concept art.Įvery book of the art-quality image you see has dozens, if not hundreds, of photos that have all played a part. It is critical to remember that it’s not just the art that matters. But, again, the goal is to limit the margin for error and save time and money. Application of Concept ArtĮthereal mood shots and more precise schematics of a prop or character are examples of concept art. All disciplines require art fundamentals, such as anatomy, perspective, color theory, design, and lighting. For freelancers, specialization is preferred above flexibility for concept artists who want to work in-house. Character drawing, monster drafting, environment drafting, and even industry-related designs are just a few of the specialties available. There are many generalist concept artists, as well as many specialized concept artists. A concept artist’s ability to create many types is highly valued. Concept artists are frequently required to conform to the style of the studio for which they are employed. Later pieces, such as matte paintings, are created with as much realism as possible. This allows for a wide range of interpretations, most of which are sketches, speed paints, and 3D overpaints. During the early ‘blue sky’ stage of production, artists working on a project frequently turn over a vast number of times. Styles in Concept Artĭepending on the requirements of the project, concept art can range from stylized to photorealistic. In addition, concept art has extended to span genres ranging from fantastical to realistic, depending on the ultimate output, since its recent use in video game production. However, science fiction and fantasy are the two most widely covered areas. Themes in Concept Artīeing the central medium in cinema poster design from the early days of Hollywood, concept art has always had to cover a wide range of subjects. Many concept projects have tight deadlines and require a highly polished item in a short amount of time. Because of the ease of editing and quickness, most concept artists have shifted to digital media. Manga Studio, Procreate, and ArtRage is among the others. Photoshop and Corel Painter are two popular applications for concept artists. Therefore, a concept artist’s ability to use painting software often depends on working with traditional media. Many modern paint packages are intended to replicate color blending in the same manner that paint would blend on a canvas. Traditional materials such as oil paintings, acrylic paints, markers, and pencils were employed prior to this. Raster graphics editors for digital painting, as well as technology such as graphics tablets, have become more widely available, allowing for more efficient working methods. Tools and Software used to Create Concept Artĭigital technology has been adopted by concept art. Commitment, vision, and explicit knowledge of the function are all required of concept artists. Film, animation, and, more recently, video game development are all examples of this. Disney employed Mary Blair to design concept paintings for “Cinderella,” “Alice in Wonderland,” and “Peter Pan.” Many artists have worked on Disney films throughout the years, producing the picturesque, imaginary worlds and characters that the franchise is famous for.Ĭoncept artists create a visual design for something that does not exist yet, such as a character or a location. The Walt Disney Animation Studios utilized the phrase “concept art” as early as the 1930s. Salary of a Concept ArtistĪ concept artist in video games earns an average of $60,000-$70,000 per year, while many earn significantly less or much more. Before moving forward with their part of the project, concept art ensures that all artists are on the same page. Animated films and video games, for example, can bring together hundreds to thousands of artists who must work together to create the final product. By using this website, you consent to the use of cookies. Our website uses cookies to help improve your visit. Also there is unRAR license restriction for some parts of the code.Read 7-Zip License information.We want you to have the best possible experience while using our service. The most of the code is under the GNU LGPL license.Some parts of the code are under the BSD 3-clause License. The program has a simple interface and lets users create backups, manage multiple files, encrypt data, and compress files.ħ-Zip is free software with open source. However, the best part is that the popular program supports a range of file formats, including ISO, RAR, LZH, TAR, GZ, TGZ, TAZ, Z, ZIPX, ZIP, and more. With the help of WinZip download for Windows, users can extract and zip files. 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